Liquorice-induced apparent mineralocorticoid excess presenting in the emergency department
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چکیده
منابع مشابه
APPARENT MINERALOCORTICOID EXCESS IN THREE SIBLINGS
Three siblings (1 boy, 2 girls) with hypertension and hypokalemia are presented, two with low plasma aldosterone and suppressed renin activity and the eldest with a high renin and aldosterone level due to secondary changes in her kidneys. Urinary tetrahydrocortisol (THF) was increased relative to tetrahydrocortisone (THE). Cortisol ring A reduction constant was also lower than normal. Thes...
متن کاملapparent mineralocorticoid excess in three siblings
three siblings (1 boy, 2 girls) with hypertension and hypokalemia are presented, two with low plasma aldosterone and suppressed renin activity and the eldest with a high renin and aldosterone level due to secondary changes in her kidneys. urinary tetrahydrocortisol (thf) was increased relative to tetrahydrocortisone (the). cortisol ring a reduction constant was also lower than normal. these fin...
متن کاملSyndrome of Apparent Mineralocorticoid Excess
The first adult case of 1 1,-hydroxysteroid dehydrogenase ( 1#6-OHSD) deficiency is described. The impaired conversion of cortisol to cortisone (indicated by urinary cortisol and cortisone metabolites and failure to metabolize 1 a-VIHlcortisol to 13H1H20), was associated with hypertension, hypokalemia, and suppression of the renin-angiotensin-aldosterone system. When established on a fixed Na+/...
متن کاملApparent mineralocorticoid excess (AME) syndrome.
Apparent mineralocorticoid excess (AME) syndrome is a rare autosomal recessive disorder due to the deficiency of 11b hydroxysteroid dehydrogenase type 2 enzyme (11beta-HSD2). Mutations in this gene affect the enzymatic activity resulting to an excess of cortisol, which causes its inappropriate access to mineralocorticoid receptor leading to inherited hypertension.This is a potentially fatal but...
متن کاملThe syndrome of apparent mineralocorticoid excess.
The elucidation of the basis of a rare inherited dis-development of hypertension, the biochemical abnormalities and the disturbances in cortisol meta-order is satisfying in itself, but particularly so if it leads to a greater understanding of normal physiology bolism.7 How then could cortisol, conventionally regarded as a glucocorticoid, act as a potent mineral-and other disease processes. Such...
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ژورنال
عنوان ژورنال: Clinical Medicine
سال: 2017
ISSN: 1470-2118,1473-4893
DOI: 10.7861/clinmedicine.17-1-43